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By Florian Holsboer, Andreas Ströhle

ISBN-10: 3540225684

ISBN-13: 9783540225683

ISBN-10: 3540280820

ISBN-13: 9783540280828

The current quantity provides a complete review at the present country of uncomplicated and scientific learn on Anxiety and Anxiolytic medicines . utilizing newly built equipment and methods researchers at the moment are starting to comprehend the molecular mechanisms of hysteria, nervousness issues and their remedy. In parallel, new drug goals were generated and the 1st medical reports with new compounds were all started. In 20 chapters written through a variety of specialists within the box complete info on all proper subject matters is supplied.

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Sample text

3 Tests for Anxiety . . . . . . . . . . . . . Behavioral Expression of Anxiety . . . . . . . . . Avoidance of Unprotected Areas as Index for Anxiety . . . Exploration: The Counterpart of Anxiety . . . . . . Risk Assessment: A Sensitive Indicator for Anxiolytic Activity? Flight-Related Behavior: A Dissociation Between Panic and Generalized Anxiety? . . Food Intake Inhibition . . . . . . . . . . . Cognition: A Primary Feature of Pathological Anxiety? .

2001; Cohen 2002). Another potential target would be the GABAergic system, which, however, seems to be involved primarily in the expression of extinction that has already been acquired and not the extinction process per se (Davis and Myers 2002). Experiments performed with d-cycloserine, an agonist of the glycine recognition site of the NMDA receptor, demonstrate how efficiently animal studies on fear extinction (Walker et al. 2002; Ledgerwood et al. 2004; Richardson et al. 2004) can be transferred into the pharmacotherapy of human anxiety disorders (Ressler et al.

The Modified Hole Board: Assessing Dimensions of Behavior . Tests for Conditioned Anxiety . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Animal Models . . . . . . . . . . . . . Genetically Based Animal Models of Anxiety . . . . . Selectively Bred Rat Lines . . . . . . . . . . Inbred Mouse Strains . . . . . . . . . . . Genetically Engineered Mice . . . .

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Anxiety and Anxiolytic Drugs by Florian Holsboer, Andreas Ströhle


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