Download PDF by Qin Wang: Advances in Adrenergic Receptor Biology

By Qin Wang

ISBN-10: 0123849217

ISBN-13: 9780123849212

This quantity of present issues in Membranes specializes in Adrenergic Receptor Biology, starting with a overview of previous successes and old views then additional discussing present normal tendencies in adrenic receptor reports in a variety of contexts. This e-book additionally comprises discussions of the function and courting of adrenergic receptors to varied platforms and ailments, setting up Adrenergic Receptor Biology as a wanted, functional reference for researchers.

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Piascik, M. , & Limbird, L. E. (1996). Central hypotensive effects of the alpha2a-adrenergic receptor subtype. Science, 273, 801–803. Maguire, M. , Van Arsdale, P. , & Gilman, A. G. (1976). An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor. Mol Pharmacol, 12, 335–339. , & Herskowitz, J. (1988). STE2 protein of Saccharomyces kluyveri is a member of the rhodopsin/beta-adrenergic receptor family and is responsible for recognition of the peptide ligand alpha factor.

Limbird, L. , (2010). Enhanced hypotensive, bradycardic, and hypnotic responses to alpha2-adrenergic agonists in spinophilinnull mice are accompanied by increased G protein coupling to the alpha2A-adrenergic receptor. Mol Pharmacol, 78, 279–286. Luttrell, L. , & Gesty-Palmer, D. (2010). Beyond desensitization: Physiological relevance of arrestin-dependent signaling. Pharmacol Rev, 62, 305–330. MacMillan, L. , Smith, M. , Piascik, M. , & Limbird, L. E. (1996). Central hypotensive effects of the alpha2a-adrenergic receptor subtype.

Biased agonism have emerged for the b3AR (Sato, Horinouchi, Hutchinson, Evans, & Summers, 2007; Sato, Hutchinson, Evans, & Summers, 2008). , 2007). Ligands, once classified according to results obtained with a single signaling readout will now have to be reassessed according to their ability to act as biased ligands in a pathway-specific manner. These inherent features of GPCRs most certainly reflect their large conformational flexibility, which is required for the diversity of their interactions with signaling partners at different stages of their life cycles.

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Advances in Adrenergic Receptor Biology by Qin Wang

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